N-Ethylcyclohexylamine

Synonym(s):N-Cyclohexylethylamine

CAS NO.：5459-93-8
Empirical Formula: C8H17N
Molecular Weight: 127.23
MDL number: MFCD00003834
EINECS: 226-733-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:26:24

What is N-Ethylcyclohexylamine ?

Chemical properties

Clear colorless liquid

The Uses of N-Ethylcyclohexylamine

Intermediate in production of herbicides and pharmaceuticals.

The Uses of N-Ethylcyclohexylamine

N-Ethylcyclohexylamine can be used in the synthesis of a series of isatin-N-Mannich bases.

Production Methods

N-Ethylcyclohexylamine is produced by hydrogenation of ethylaniline at 180 ℃ and 6 MPa or by amination of cyclohexanone under hydrogenation conditions in the presence of ethylamine. The amine is a starting material for the preplant sugar beet, grass, and spinach herbicide cycloate (Zeneca's Ro-Neet), which is obtained by converting N-ethylcyclohexylamine into S-ethyl-N-ethyl-N-cyclohexylthiocarbamate. A minor use of N-ethylcyclohexylamine is for vulcanization accelerators.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 6749, 1996 DOI: 10.1016/S0040-4039(96)01458-X

General Description

A clear colorless liquid with an ammonia-like odor. Floats on water and slightly soluble in water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

N-Ethylcyclohexylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Corrosive and toxic.

Health Hazard

Inhalation of high concentration of vapor will produce irritation of the respiratory tract and lungs. Inhalation of large quantities of vapor may be fatal.

Fire Hazard

Behavior in Fire: Dangerous when exposed to heat or flame. Can react vigorously with oxidizing materials.

Safety Profile

Moderately toxic by ingestion, inhalation, and skin contact. A severe skin and eye irritant. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fKe, use alcohol foam, mist, spray, dry chemical. See also AMINES

Properties of N-Ethylcyclohexylamine

Melting point:	-15°C (estimate)
Boiling point:	165 °C (lit.)
Density	0.844 g/mL at 25 °C (lit.)
vapor density	4.4 (vs air)
vapor pressure	2 mm Hg ( 20 °C)
refractive index	n20/D 1.452(lit.)
Flash point:	111 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Liquid
pka	11.16±0.20(Predicted)
color	Clear colorless to light yellow
explosive limit	7.6%
BRN	2070280
CAS DataBase Reference	5459-93-8(CAS DataBase Reference)
NIST Chemistry Reference	Cyclohexanamine, N-ethyl-(5459-93-8)
EPA Substance Registry System	N-Ethylcyclohexylamine (5459-93-8)

Safety information for N-Ethylcyclohexylamine

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H311:Acute toxicity,dermal H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.