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Home Product name listN-Cbz-L-Leucine

N-Cbz-L-Leucine

Synonym(s):N-(Benzyloxycarbonyl)leucine;N-(Benzyloxycarbonyl)-L-leucine;N-(Carbobenzoxy)leucine;N-(Phenylmethoxy)carbonyl-L-leucine;N-Carbobenzoxy-L-leucine

CAS NO.：2018-66-8
Empirical Formula: C14H19NO4
Molecular Weight: 265.3
MDL number: MFCD00026494
EINECS: 217-960-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-17 10:44:43

N-Cbz-L-Leucine Structural

What is N-Cbz-L-Leucine?

Chemical properties

yellow oil or weak solid

The Uses of N-Cbz-L-Leucine

Reactant for:

Peptide-based preparation of potential antitumor agents
Preparation of cyclopropyl peptidomimetics
Peptide synthesis

Definition

ChEBI: A L-leucine derivative obtained by the substitution of a benzyloxycarbonyl group on the nitrogen atom.

Properties of N-Cbz-L-Leucine

Boiling point:	408.52°C (rough estimate)
alpha	-17 º (c=2, ethanol)
Density	1 g/mL at 25 °C(lit.)
refractive index	n20/D 1.512(lit.)
Flash point:	85 °F
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	viscous liquid
pka	4.00±0.21(Predicted)
Specific Gravity	1.0
color	Colorless to Light yellow
optical activity	[α]20/D 17°, c = 2 in ethanol
Water Solubility	Not miscible or difficult to mix in water. Soluble in chloroform, DMSO and methanol.
BRN	1253861
CAS DataBase Reference	2018-66-8(CAS DataBase Reference)

Safety information for N-Cbz-L-Leucine

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Health Hazard GHS08
GHS Hazard Statements	H226:Flammable liquids H351:Carcinogenicity
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use … for extinction.

Computed Descriptors for N-Cbz-L-Leucine

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