N-BOC-4-Hydroxypiperidine

Synonym(s):tert-Butyl 4-hydroxy-1-piperidinecarboxylate;1-Boc-4-piperidinol

CAS NO.：109384-19-2
Empirical Formula: C10H19NO3
Molecular Weight: 201.26
MDL number: MFCD01075174
EINECS: 600-916-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-17 16:11:33

What is N-BOC-4-Hydroxypiperidine?

Chemical properties

White to cream powder

The Uses of N-BOC-4-Hydroxypiperidine

N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.

The Uses of N-BOC-4-Hydroxypiperidine

Used in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction.

Preparation

A mixture of 4-hydroxypiperidine (10.0 g, 98. 9 mmol), aqueous sodiumhydrogen carbonate (150 mL, 1 M), DI-FERT-BUTYL dicarbonate (21. 6 g, 98.9 mmol) and dichloromethane was stirred for 15 h. The phases were separated and the product (N-BOC-4-Hydroxypiperidine) was isolated as an oil in quantitative yield (19.9 g).

Properties of N-BOC-4-Hydroxypiperidine

Melting point:	61-65 °C (lit.)
Boiling point:	292.3±33.0 °C(Predicted)
Density	1.107±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate
form	Powder
pka	14.80±0.20(Predicted)
color	White to cream
BRN	7202094
InChI	InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-8(12)5-7-11/h8,12H,4-7H2,1-3H3
CAS DataBase Reference	109384-19-2(CAS DataBase Reference)

Safety information for N-BOC-4-Hydroxypiperidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.