N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)

CAS NO.：1314212-39-9
Empirical Formula: C20H18Cl2N2O2
Molecular Weight: 389.28
MDL number: MFCD28386025
Update Date: 2025-04-17 18:22:24

What is N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)?

Biological Activity

CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2]. CYM50358 shows less potent inhibition of S1PR1 (IC50=6.4 μM)[1].CYM50358 (10 μM) has no effect on the collagen-induced HSP27 phosphorylation, markedly reverses the suppressive effect of S1P on the collagen-induced phosphorylation of HSP27[2].

References

[1]. Guerrero M, et, al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6. [2]. Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.

Properties of N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)

Boiling point:	463.5±45.0 °C(Predicted)
Density	1.329±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 125 mg/mL (321.11 mM; Need ultrasonic)
form	Solid
pka	12.40±0.70(Predicted)
color	Off-white to yellow

Safety information for N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)

Computed Descriptors for N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide(CYM50358)

New Products

Sodium glycochenodeoxycholate, >98% Indole Methyl Resin tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Gabapentin EP Impurity A 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidamide 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 1,3-Diphenylurea 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID N-METHYL INDAZOLE-3-CARBOXYLIC ACID Zinc Bis-glycinate 2-Hydroxy-5-nitroacetophenone 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile 1,3-Diethyl-1,3-Diphenylurea Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2-HYDROXY BENZYL CYANIDE DIETHYL AMINOMALONATE HYDROCHLORIDE 5-BROMO-2CYANO PYRIDINE Boldenone Clarithromycin Ethinyl Estradiol Stanozolol

Related products of tetrahydrofuran

N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride

1-[2-(1-Benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxo-ethyl]-6-oxo-1,6-dihydro-pyridine-3-carbonitrile

CYM50308

CYM50179