MOZ-IN-3
- CAS NO.：2055397-18-5
- Empirical Formula: C20H17FN2O3S
- Molecular Weight: 384.42
- Update Date: 2026-02-02 18:10:39
What is MOZ-IN-3?
Description
MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.
The Uses of MOZ-IN-3
MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.
Storage
Store at -20°C
Properties of MOZ-IN-3
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml; DMSO: 33 mg/ml; Ethanol: 2 mg/ml |
| form | A crystalline solid |
| pka | 7.15±0.25(Predicted) |
| color | White to off-white |
Safety information for MOZ-IN-3
Computed Descriptors for MOZ-IN-3
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