MKC3946
- CAS NO.：1093119-54-0
- Empirical Formula: C21H20N2O3S
- Molecular Weight: 380.46
- Update Date: 2025-12-05 14:33:18
What is MKC3946?
Biological Activity
MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.
in vivo
In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.
Properties of MKC3946
| Boiling point: | 591.6±50.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM) |
| form | A crystalline solid |
| pka | 8.18±0.50(Predicted) |
| color | White to yellow |
Safety information for MKC3946
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MKC3946
New Products
4-Bromo-2-chlorobenzonitrile 1-Chloro-4-Methyl-2-Nitrobenzene 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile Chlorodehydromethyl testosterone Cisplatin Prednisolone acetate Trenbolone Enanthate Benzethonium Chloride Testosterone acetate 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 3-Hydroxy-4-nitrobromobenzene 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Boc-L-Leucinol Calcium Ascorbate Boc-Tyr-OH tert-butyl 2-oxo-1,4,9-triazaspiro[5.5]undecane-9-carboxylate 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-1H-pyrazole-4-carboxylic acid (1R,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-oneRelated products of tetrahydrofuran
You may like
-
IRE1α Inhibitor, MKC-3946 CAS 1093119-54-0View Details
1093119-54-0 -
2124221-11-8 (4-(methylamino)phenyl)methanesulfonic acid 98%View Details
2124221-11-8 -
Boc-Arg-OH HCl H2O 114622-81-0 98%View Details
114622-81-0 -
2-(2-chloropyrimidin-4-yl)acetic acid 98%View Details
1211581-39-3 -
15761-38-3 Boc-Ala-OH 98%View Details
15761-38-3 -
42074-68-0 98%View Details
42074-68-0 -
20866-46-0 Boc-His(Boc)-OH 98%View Details
20866-46-0 -
2-(4-(tert-butoxycarbonyl)piperazin-2-yl)acetic acid 98%View Details
183591-72-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.