MKC3946
- CAS NO.：1093119-54-0
- Empirical Formula: C21H20N2O3S
- Molecular Weight: 380.46
- Update Date: 2026-06-03 11:24:09
What is MKC3946?
Biological Activity
MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.
in vivo
In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.
Properties of MKC3946
| Boiling point: | 591.6±50.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM) |
| form | A crystalline solid |
| pka | 8.18±0.50(Predicted) |
| color | White to yellow |
Safety information for MKC3946
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MKC3946
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