MILBEMECTIN A4

CAS NO.：51596-11-3
Empirical Formula: C32H46O7
Molecular Weight: 542.7
MDL number: MFCD04972570
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:36:23

What is MILBEMECTIN A4?

Description

Milbemycin A₄ is the prominent member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin ₄ is used as a nematocide and insecticide.

The Uses of MILBEMECTIN A4

Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A4 is the dominant member of a group of analogues containing a 25-ethyl substituent. Milbemycin A4 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels.

The Uses of MILBEMECTIN A4

Acaricide.

The Uses of MILBEMECTIN A4

Milbemycin A4 is a macrolide compound that is a member of a complex family of macrocyclic lactones that contain structural group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. Antibacterial and insecticide (1,2). It potentiates glutamate and GABA-gated chloride-channel opening. Used in the synthesis of Milbemycin A17 (3).

What are the applications of Application

Milbemycin A4 is an antibiotic with acaricidal activity

Definition

ChEBI: Milbemycin A4 is a milbemycin.

Properties of MILBEMECTIN A4

Melting point:	212-215°
Boiling point:	732.9±60.0 °C(Predicted)
alpha	D20 +106° (c = 0.25 in acetone)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	0-6°C
solubility	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form	A solid
pka	12.46±0.70(Predicted)
color	White to off-white
EPA Substance Registry System	Milbemycin A4 (51596-11-3)