metopimazine

Chemical properties

Pale Yellow Solid

Originator

Nortrip,Rhodia

The Uses of metopimazine

metopimazine is used to prevent emesis during chemotherapies.

The Uses of metopimazine

Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.

What are the applications of Application

Metopimazine is a dopamine receptor antagonist

Definition

ChEBI: Metopimazine is a member of phenothiazines.

Manufacturing Process

2-Methylsulfonyl-10-(3-chloropropyl)phenothiazine was prepared by condensation of 1-bromo-3-chloropropane and 2-methylsulfonyl phenothiazine in liquid ammonia in presence of obtained in situ sodium amide.
10 g 2-methylsulfonyl-10-(3-chloropropyl)-phenothiazine, 4 g piperidine-4- carboxylic acid amide, 3.5 g dry sodium carbonate in 200 ml of ethanol was heated to reflux for 24 hours. Than 1.75 g sodium carbonate was added and the mixture was heated another 8 hours. After that the new 1.75 g portion of sodium carbonate was added and heated for 16 hours. The solvent was removed in vacuum (20 mm Hg). The residue was stirred with 50 ml water and 150 ml ethyl acetate. The organic layer was separated and extracted with 200 ml 1 N hydrochloric acid. The water layer was made alkaline with 4 N sodium hydroxide, extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed in vacuum (20 mm Hg) to dryness. The obtained residue 2-methylsulfonyl-10-(3-(4-carbamoylpiperidino)propyl)phenothiazine was recrystallized from ethyl acetate. Yield 6 g; MP: 170°-171°C.

Therapeutic Function

Antiemetic