METHYLDICHLOROPHOSPHINE
Synonym(s):Methyldichlorophosphine;Methylphosphinic dichloride;Methylphosphinous dichloride;Methylphosphonous dichloride;Methylphosphorus dichloride
- CAS NO.：676-83-5
- Empirical Formula: CH3Cl2P
- Molecular Weight: 116.91
- MDL number: MFCD00013616
- EINECS: 211-631-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:21:01
What is METHYLDICHLOROPHOSPHINE?
Chemical properties
Colorless to light yellow liqui
The Uses of METHYLDICHLOROPHOSPHINE
Methyldichlorophosphine is used to prepare difunctional phosphonoamidite coupling reagents in nucleoside chemistry and "phospha-Wittig"reagents.
General Description
A colorless liquid with a pungent odor. Very toxic by inhalation. Denser than water.
Air & Water Reactions
Highly flammable. Forms fumes containing HCl in moist air. Can spontaneously ignite on contact with moist air. Reacts with water to form hydrochloric acid, reaction may be violent and ignite unreacted material.
Reactivity Profile
METHYLDICHLOROPHOSPHINE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Fire will produce irritating, corrosive and/or toxic gases. Inhalation of decomposition products may cause severe injury or death. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard
Flammable/combustible material. May ignite on contact with moist air or moisture. May burn rapidly with flare-burning effect. Some react vigorously or explosively on contact with water. Some may decompose explosively when heated or involved in a fire. May re-ignite after fire is extinguished. Runoff may create fire or explosion hazard. Containers may explode when heated.
Safety Profile
A poison. A corrosive irritant to the skin, eyes, and mucous membranes. Flammable when exposed to heat or flame; can react vigorously with oxidtzing materials. When heated to decomposition it emits very toxic fumes of Cland POx.
Properties of METHYLDICHLOROPHOSPHINE
| Melting point: | 81.5 °C |
| Boiling point: | 81-82 °C |
| Density | 1.3 |
| refractive index | 1.4944-1.4964 |
| Flash point: | 48 °C |
| storage temp. | Flammables area |
| form | Liquid |
| color | Colorless |
| Water Solubility | Reacts with water. |
| Sensitive | Air & Moisture Sensitive |
| EPA Substance Registry System | Methylphosphonous dichloride (676-83-5) |
Safety information for METHYLDICHLOROPHOSPHINE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H226:Flammable liquids H250:Pyrophoric liquids; Pyrorophoric solids H252:Self-heating substances and mixtures H301:Acute toxicity,oral H311:Acute toxicity,dermal H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H331:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P222:Do not allow contact with air. P231:Handle under inert gas. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P422:Store contents under … |
Computed Descriptors for METHYLDICHLOROPHOSPHINE
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