Methyl malonyl chloride
Synonym(s):Methyl chloroformylacetate;Methyl malonyl chloride
- CAS NO.：37517-81-0
- Empirical Formula: C4H5ClO3
- Molecular Weight: 136.53
- MDL number: MFCD00013657
- EINECS: 253-540-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:18
What is Methyl malonyl chloride?
Chemical properties
Clear light yellow to yellow liquid
The Uses of Methyl malonyl chloride
Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs.
General Description
Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates.
Properties of Methyl malonyl chloride
| Boiling point: | 57-59 °C/12 mmHg (lit.) |
| Density | 1.273 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 176 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, Ethyl Acetate |
| pka | 9.33±0.46(Predicted) |
| form | Liquid |
| color | Colorless |
| Specific Gravity | 1.275 |
| Water Solubility | Reacts with water. |
| Sensitive | Lachrymatory |
| BRN | 1754078 |
| CAS DataBase Reference | 37517-81-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Methyl malonyl chloride(37517-81-0) |
Safety information for Methyl malonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl malonyl chloride
| InChIKey | UTBCRHAMJFMIIR-UHFFFAOYSA-N |
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