Methyl indole-3-carboxylate

Chemical properties

light brown amorphous powder

The Uses of Methyl indole-3-carboxylate

Methyl indole-3-carboxylate is a reagent in the preaparation of oncrasin-1 derivatives which is a novel inhibitor of the C-terminal domain of RNA polymerase II.

The Uses of Methyl indole-3-carboxylate

Reactant for preparation of:

• Nitric oxide synthase (nNOS) inhibitorS
• Protein kinase c alpha (PKCα) inhibitors
• Inhibitors of the C-terminal domain of RNA polymerase II as antitumor agents
• Kinase insert domain receptor (KDR) inhibitors
• Organocatalysts for the anti-Mannich reaction
• Very late antigen-4 (VLA-4) antagonists
• Inhibitors of Human 5-Lipoxygenase
• Serotonin 5-HT4 receptor antagonists
• Hyaluronidase inhibitors

• Enantioselective Meerwein-Eschenmoser Claisen rearrangement reactions?

Definition

ChEBI: Methyl indole-3-carboxylate is the methyl ester of indole-3-carboxylic acid. It has a role as a metabolite. It is a member of indoles and a methyl ester. It is functionally related to an indole-3-carboxylic acid.

General Description

Methyl indole-3-carboxylate (3-Methoxycarbonylindole, 3-Carbomethoxyindole, Methyl indolyl-3-carboxylate) has been extracted from the marine Streptomyces sp. 060524. Its crystal structure indicates the presence of inter-molecular N-H…O hydrogen bond. It is also obtained during the isolation of sorazinones A and B from Sorangium cellulosum strain Soce895. It undergoes regioselective dibromination with bromine in acetic acid to afford methyl 5,6-dibromoindole-3-carboxylate.