methyl 3-(4-methylphenylsulfonamido)benzoate

Synonym(s):3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester;Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate;WI-21

CAS NO.：173436-66-3
Empirical Formula: C15H15NO4S
Molecular Weight: 305.35
MDL number: MFCD00994918
Update Date: 2026-01-13 11:22:46

methyl 3-(4-methylphenylsulfonamido)benzoate Structural

What is methyl 3-(4-methylphenylsulfonamido)benzoate?

Biochem/physiol Actions

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

Properties of methyl 3-(4-methylphenylsulfonamido)benzoate

Melting point:	152-154 °C
Boiling point:	456.5±55.0 °C(Predicted)
Density	1.312±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	7.88±0.10(Predicted)
form	powder
color	off-white to purple

Safety information for methyl 3-(4-methylphenylsulfonamido)benzoate

Computed Descriptors for methyl 3-(4-methylphenylsulfonamido)benzoate

New Products

Cyclopropane-1,1-dicarboxylic acid Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity tert-Butyl (2S)-[1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]carbamate 4-amino-2-fluoro-N- methylbenzamide 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine N-Boc-1,4-butanediamine 4-Bromo-2-fluoro-N-methylbenzamide valeronitrile 3-chlorobenzyl cyanide 3,4 Dimethoxy Benzylcyanide 3,4 Diethoxy Benzylcyanide 2-Chloro Benzylcyanide 3-Hydroxypropionitrile 5-azidovalericacid 6,6'-bis(difluoromethoxy)-2,2'-bis((3,4-dimethoxypyridin-2-yl)methylsulfinyl)-1H,1'H-5,5'-bibenzo[d]imidazole (1-((2'-(2-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (1-((2'-(1-((1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol (4-Methoxyphenyl) hydrazine Hydrochloride