methyl 3-(4-methylphenylsulfonamido)benzoate

Synonym(s):3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester;Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate;WI-21

CAS NO.：173436-66-3
Empirical Formula: C15H15NO4S
Molecular Weight: 305.35
MDL number: MFCD00994918
Update Date: 2026-04-24 14:59:10

methyl 3-(4-methylphenylsulfonamido)benzoate Structural

What is methyl 3-(4-methylphenylsulfonamido)benzoate?

Biochem/physiol Actions

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

Properties of methyl 3-(4-methylphenylsulfonamido)benzoate

Melting point:	152-154 °C
Boiling point:	456.5±55.0 °C(Predicted)
Density	1.312±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	7.88±0.10(Predicted)
form	powder
color	off-white to purple

Safety information for methyl 3-(4-methylphenylsulfonamido)benzoate

Computed Descriptors for methyl 3-(4-methylphenylsulfonamido)benzoate

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