Methyl 2,5-dihydroxybenzoate
Synonym(s):Methyl gentisate
- CAS NO.：2150-46-1
- Empirical Formula: C8H8O4
- Molecular Weight: 168.15
- MDL number: MFCD00016464
- EINECS: 218-427-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:20:42
What is Methyl 2,5-dihydroxybenzoate?
The Uses of Methyl 2,5-dihydroxybenzoate
Methyl 2,5-dihydroxybenzoate (methyl gentisate) may be used as a starting material in the synthesis of euonyminol.
The Uses of Methyl 2,5-dihydroxybenzoate
methyl gentisate is also known as methyl dihydroxybenzoate. It is a skin-lightening ingredient that acts by inhibiting the melanocyte’s production of tyrosinase. It can be naturally obtained from gentian root.
Definition
ChEBI: Methyl 2,5-dihydroxybenzoate is a member of phenols and a benzoate ester.
General Description
Methyl 2,5-dihydroxybenzoate (methyl gentisate) is an alkyl ester of gentisic acid. It is reported to show less cytotoxic and mutagenic activity than hydroquinone with a potential to inhibit melanogenesis. It has been synthesized from 2,5-dihydroxybenzoic acid. The crystal structure of the molecule was found to be planar.
Properties of Methyl 2,5-dihydroxybenzoate
| Melting point: | 86-88 °C (lit.) |
| Boiling point: | 136 °C / 1mmHg |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.87±0.18(Predicted) |
| color | Off-White to Pale Beige |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 2150-46-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 2,5-dihydroxy-, methyl ester(2150-46-1) |
Safety information for Methyl 2,5-dihydroxybenzoate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl 2,5-dihydroxybenzoate
| InChIKey | XGDPKUKRQHHZTH-UHFFFAOYSA-N |
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