Methyl 2-methyl-3-nitrobenzoate
Synonym(s):Methyl 3-nitro-o-toluate
- CAS NO.：59382-59-1
- Empirical Formula: C9H9NO4
- Molecular Weight: 195.17
- MDL number: MFCD00082564
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:50:10
What is Methyl 2-methyl-3-nitrobenzoate?
Description
Methyl 2-methyl-3-nitrobenzoate is an important organic synthetic material and pharmaceutical intermediate compound. It can be used for the preparation of the anticancer drug lenalidomide as well as other organic compounds (e.g., indole-4-carboxylic acid methyl ester, 5-nitroisocoumarin, 5-aminoisoquinolin-1(2H)-one, etc.).
Chemical properties
White crystalline powder
The Uses of Methyl 2-methyl-3-nitrobenzoate
Methyl 2-methyl-3-nitrobenzoate may be used in the synthesis of methyl indole-4-carboxylate, 5-aminoisoquinolin-1(2H)-one, 5-nitroisocoumarin and [2-(4-fluorophenyl)-1H-indol-4-yl]-1-pyrrolidinylmethanone. It may also be used in the preparation of substituted nitrostyrene benzoic acids, via reaction with aromatic aldehydes in the presence of DBU in DMSO; and 4-(hydroxymethyl)-1-tosylindole, via Batcho-Leimgruber modification of the Reissert indole synthesis.
The Uses of Methyl 2-methyl-3-nitrobenzoate
Methyl 2-methyl-3-nitrobenzoate may be used in the synthesis of:
- methyl indole-4-carboxylate
- 5-aminoisoquinolin-1(2H)-one
- 5-nitroisocoumarin
- substituted nitrostyrene benzoic acids, via reaction with aromatic aldehydes in the presence of DBU in DMSO
- 4-(hydroxymethyl)-1-tosylindole, via Batcho-Leimgruber modification of the Reissert indole synthesis
- [2-(4-fluorophenyl)-1H-indol-4-yl]-1-pyrrolidinylmethanone
Solubility in organics
Soluble in methanol.
Properties of Methyl 2-methyl-3-nitrobenzoate
| Melting point: | 62-65 °C (lit.) |
| Boiling point: | 286.6±20.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| form | Solid |
| color | Pale Beige |
| BRN | 1964020 |
| CAS DataBase Reference | 59382-59-1(CAS DataBase Reference) |
Safety information for Methyl 2-methyl-3-nitrobenzoate
Computed Descriptors for Methyl 2-methyl-3-nitrobenzoate
New Products
2-Bromo-4-hydroxypyridine Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Cis-Tosylate 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 2'-Fluoroacetophenone 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID N-Methyl-2-amino-2-methylpropionamide 4-(FMOC-AMINO)-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 2-(2-Bromophenyl)ethanol Boc-D-Glu(OMe)-OMe 2,5 Dibromopyridine Ethyl 4-hydroxy-3-oxobutanoate Dimethyl (2S)-2-((tert-butoxycarbonyl)amino)-4-(cyanomethyl)pentanedioate 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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