MELPERONE
- CAS NO.：3575-80-2
- Empirical Formula: C16H22FNO
- Molecular Weight: 263.35
- MDL number: MFCD00867737
- EINECS: 609-173-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is MELPERONE?
Originator
Eunerpan,Nordmark,W. Germany,1965
Definition
ChEBI: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone is an aromatic ketone.
Manufacturing Process
A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C.
Therapeutic Function
Neuroleptic
Properties of MELPERONE
| Melting point: | 78.0 to 82.0 °C |
| Boiling point: | bp0.1 120-125° |
| Density | 1.046±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 41.67 mg/mL (158.23 mM) |
| pka | 9.34±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Merck | 14,5827 |
Safety information for MELPERONE
Computed Descriptors for MELPERONE
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline 5-Hydroxy-3,9-dimethyl-7H-benzo[c]fluoren-7-one Methyl 4-(acetyloxy)-6-methoxy-1-(4-methoxyphenyl)-2naphthalenecarboxylate 4-Hydroxy-6,7-dimethoxy-1-phenyl-2naphthalenecarboxylic acid (3,5-Dibromophenyl)[4-(trifluoromethyl)phenyl]methanone (4-butoxyphenyl)(4-fluorophenyl)methanone (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide 4-Ethyl-4-hydroxy-1,4,7,8-tetrahydro-3H,10H-spiro[pyrano[3,4-f]indolizine-6,2'-[1,3]dioxolane]-3,10-dione (E)-N'-(2-cyano-4-nitrophenyl)- N,N-dimethylformimidamide 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid Benzyl-N,4-dimethylpiperidine-3- amine dihydrochloride 5-bromopyridin-2-amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3-chlorobenzyl cyanide 3,4 Dimethoxy BenzylcyanideRelated products of tetrahydrofuran
![SPIPERONE, [BENZENE RING-3H]](https://img.chemicalbook.in/CAS/GIF/80154-50-3.gif)
![N-METHYL-8-[4-(4-FLUOROPHENYL)-4-OXOBUTYL]-1-PHENYL-1,3,8-TRIAZASPIRO-[4.5]DECAN-4-ONE HYDROCHLORIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure1/GIF/CB1219384.gif)
![METHYLSPIPERONE, [N-METHYL-3H]](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB3167067.gif)
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