Mal-PEG1-acid
- CAS NO.：760952-64-5
- Empirical Formula: C9H11NO5
- Molecular Weight: 213.19
- MDL number: MFCD24497443
- Update Date: 2026-05-28 06:27:48
What is Mal-PEG1-acid?
Description
Mal-PEG1-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Mal-PEG1-acid is a non-cleavable ADC linker containing 1 unit PEG, which can be used to synthesize antibody drug conjugates (ADC),it is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of Mal-PEG1-acid
| Boiling point: | 419.4±30.0 °C(Predicted) |
| Density | 1.383±0.06 g/cm3(Predicted) |
| pka | 4.27±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for Mal-PEG1-acid
Computed Descriptors for Mal-PEG1-acid
New Products
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