Madrasin

Synonym(s):2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one;2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI);4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI);4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-;RNAsplicing inhibitor

CAS NO.：374913-63-0
Empirical Formula: C16H17N5O2
Molecular Weight: 311.34
MDL number: MFCD02233199
Update Date: 2025-12-15 14:23:52

What is Madrasin?

The Uses of Madrasin

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.

Definition

ChEBI: 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one is a member of quinazolines.

Biochem/physiol Actions

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.

Properties of Madrasin

storage temp.	2-8°C
solubility	DMSO:1.5(Max Conc. mg/mL);4.82(Max Conc. mM)
form	powder
color	white to dark brown

Safety information for Madrasin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral

Computed Descriptors for Madrasin

New Products

Indole Methyl Resin tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidamide 4-chloromethyl-5-methyl-1,3-dioxol-2-one (DMDO-Cl) 2,2-Dimethoxy-7-azaspiro[3.5]nonane hydrochloride 1-Boc-4-cyanopiperidine R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDIIMIDAZOLE 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) Methyl 6-methylnicotinate TETRAHYDRO-2H-PYRAN-3-OL tert-Butyl carbazate 2-Methoxyphenothiazine N-methyl -4-piperidone 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 2,4-dihydroxybenzaldehyde 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,6-dichloro-4-nitropyridine 4-Bromo-2-chlorobenzonitrile 1-methylindoline-2,3-dione methyl 4-ethyl-3-ethynylbenzoate Methyl phenyl sulfone