LY2584702

CAS NO.：1082949-67-4
Empirical Formula: C21H19F4N7
Molecular Weight: 445.42
MDL number: MFCD18633220
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-20 19:14:41

What is LY2584702?

Description

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.

The Uses of LY2584702

LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

References

1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

Properties of LY2584702

storage temp.	RT (des.)
solubility	Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
form	solid
color	Yellow
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.