LUZINDOLE
Synonym(s):N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide;N-Acetyl-2-benzyltryptamine
- CAS NO.：117946-91-5
- Empirical Formula: C19H20N2O
- Molecular Weight: 292.37
- MDL number: MFCD00672498
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:57
What is LUZINDOLE?
Chemical properties
Off-White Amorphous Solid
The Uses of LUZINDOLE
Luzindole significantly antagonizes melatonin-mediated antinociception, suggesting that MEL-1B-R plays a further role as a mediator of melatonin modulation of pain signaling. It is used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways, including circadian rhythms, animal behavior, and melanophore response
The Uses of LUZINDOLE
A melatonin receptor antagonist
What are the applications of Application
Luzindole is a selective antagonist of MEL-1B-R (melatonin receptor)
Definition
ChEBI: A member of the class of indoles that is tryptamine in which one of the amino hydrogens is replaced by an acetyl group while the hydrogen at position 2 is replaced by a benzyl group.
Biological Activity
Melatonin antagonist.
Biochem/physiol Actions
Luzindole is a melatonin (mel) receptor antagonist. It has higher affinity towards the Mel 1b receptor than the Mel 1a receptor subtype.
Storage
Store at -20°C
Properties of LUZINDOLE
| Melting point: | 44-46°C |
| Boiling point: | 434.31°C (rough estimate) |
| Density | 1.1045 (rough estimate) |
| refractive index | 1.6140 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: 5 mg/mL |
| form | White to off-white crystalline solid. |
| pka | 16.36±0.46(Predicted) |
| color | Off-White to Yellow |
| Water Solubility | Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water. |
| Stability: | Store at -20°C |
| CAS DataBase Reference | 117946-91-5(CAS DataBase Reference) |
Safety information for LUZINDOLE
Computed Descriptors for LUZINDOLE
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloropyridazine 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 6-Methyl-2-pyridinemethanol 2-Pyridinecarboxaldehdye tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 1-Indanone 2-Chloromethyl-6-methyl-pyridine 4-Morpholinoaniline Abiraterone Ethyl Ether 1-nitro-3,5-dimethyl adamantine (NMEM) Vardenafil Bis-sulphonamide(Dimer) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneRelated products of tetrahydrofuran
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