LMTK3 inibitor C28

CAS NO.：2764850-23-7
Empirical Formula: C18H11F3N4O
Molecular Weight: 356.31
Update Date: 2026-01-13 11:12:55

What is LMTK3 inibitor C28?

Biological Activity

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.

Storage

Store at -20°C

Properties of LMTK3 inibitor C28

solubility	Soluble to 50 mM in DMSO and to 20 mM in ethanol
form	Solid
color	Light yellow to yellow

Safety information for LMTK3 inibitor C28

Computed Descriptors for LMTK3 inibitor C28

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