LMPTP inhibitor1

CAS NO.：1908414-82-3
Empirical Formula: C28H36N4O
Molecular Weight: 444.61
Update Date: 2026-07-27 17:00:41

What is LMPTP inhibitor1?

Description

LMW-PTP inhibitor I is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC₅₀ = 0.8 μM). It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 μM. LMW-PTP inhibitor I increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 μM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.

Properties of LMPTP inhibitor1

Boiling point:	657.7±55.0 °C(Predicted)
Density	1.121±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 20mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,PBS (pH 7.2): 3mg/mL
pka	9.48±0.10(Predicted)

Safety information for LMPTP inhibitor1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for LMPTP inhibitor1

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