LM22B-10

Synonym(s):2,2′,2′′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis[ethanol];2,2′,2′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

CAS NO.：342777-54-2
Empirical Formula: C27H33ClN2O4
Molecular Weight: 485.01
MDL number: MFCD00483554
Update Date: 2026-04-21 10:31:43

What is LM22B-10?

The Uses of LM22B-10

LM22B-10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

Storage

Store at -20°C

Properties of LM22B-10

Boiling point:	718.9±60.0 °C(Predicted)
Density	1.287±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form	A crystalline solid
pka	14.00±0.10(Predicted)
color	Light green to green

Safety information for LM22B-10

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for LM22B-10

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