Limonin
Synonym(s):Citrolimonin;Dictamnolactone;Evodin;Limonoic acid 3,19:16,17 dilactone;Obaculactone
- CAS NO.：1180-71-8
- Empirical Formula: C26H30O8
- Molecular Weight: 470.51
- MDL number: MFCD00075922
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 15:16:37
What is Limonin?
Chemical properties
White powder
The Uses of Limonin
antiproliferative, antiviral, antiinflammatory, antinociceptive
The Uses of Limonin
Limonin is a limonoid extracted from various citrus plants. Bioactivity of Limonin have been revolved around its anti-HIV properties.
The Uses of Limonin
Limonin has been used:
- to treat human peripheral blood mononuclear cells (PBMCs) to test its effect on human immunodeficiency virus (HIV) replication
- to test its effects as an anti-osteoporosis agent in osteoblastogenesis activity in MC3T3-E1 cells and ovariectomized (OVX) rat model
- as a reference standard in high-performance liquid chromatography (HPLC) system
Definition
ChEBI: Limonin is a limonoid, an epoxide, a hexacyclic triterpenoid, a member of furans, an organic heterohexacyclic compound and a lactone. It has a role as a metabolite, an inhibitor and a volatile oil component.
What are the applications of Application
Limonin is a chemically induced carcinogenesis inhibitor
General Description
Limonin is a limonoid glycoside with cancer chemo-preventive activity.
Biochem/physiol Actions
Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. It has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. It also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity.
Properties of Limonin
| Melting point: | 298 C |
| alpha | D -128° (c = 1.21 in acetone) |
| Boiling point: | 67 °C |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Sparingly) |
| form | neat |
| form | Solid |
| color | White to Off-White |
| λmax | 285nm(lit.) |
| Merck | 14,5494 |
| EPA Substance Registry System | Limonin (1180-71-8) |
Safety information for Limonin
Computed Descriptors for Limonin
New Products
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