licarin A
- CAS NO.：51020-86-1
- Empirical Formula: C20H22O4
- Molecular Weight: 326.39
- MDL number: MFCD20260801
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is licarin A?
Biological Activity
Licarin A ((+)-Licarin A), which can be isolated from a variety of plants, significantly reduces dinitrophenylhydrazine-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. It has anti-allergic effect and reduces TNF-α and PGD2 production, and COX-2 expression.
in vitro
Licarin A is found in plants such as Aristolochia taliscana , Machilus thunbergii and Myristica fragrans , which are used as spices and in folk medicines for nervous and digestive disorders. It also exhibits anti-inflammatory effects.
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels.
Properties of licarin A
| storage temp. | 4°C, protect from light |
| form | Solid |
| color | White to off-white |
Safety information for licarin A
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for licarin A
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