Levosulpiride

Chemical properties

White Solid

The Uses of Levosulpiride

Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic.

The Uses of Levosulpiride

dopamine receptor antagonists

The Uses of Levosulpiride

(S)-(?)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹

What are the applications of Application

(S)-(?)-Sulpiride is a D2DR inhibitor

Definition

ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, 1 and D5 receptors respectively).

General Description

(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.

Biological Activity

Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).

Biochem/physiol Actions

(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

Storage

Room temperature