Levocetirizine dihydrochloride

The Uses of Levocetirizine dihydrochloride

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.

The Uses of Levocetirizine dihydrochloride

Anti Histaminic

General Description

Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is a white, crystalline powder and is water soluble. This R-enantiomer has a 30-fold higher affinity than the S-enantiomer and dissociates more slowly from H1-receptors. Pharmacologically, it displays the same receptor and CNS selectivity profile as the racemate, cetirizine, and thus the same therapeutic advantages. Levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older and for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older. Its pharmacokinetics and clearance profile are essentially the same as the racemate, cetirizine.

Biochem/physiol Actions

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Side Effects

Some people may experience some side effects from levocetirizine. One must stop taking the medication if the following symptoms appear: Fatigue, Mouth parchedness, Weakness, Fever, nose bleeding, Throat discomfort, Sleepiness, Rashes all over the body, Itching and burning, Round and raised red spots on the skin, and Cough.