LE 300
- CAS NO.：274694-98-3
- Empirical Formula: C20H22N2
- Molecular Weight: 290.4
- MDL number: MFCD00951284
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-05 11:31:08
What is LE 300?
Description
LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).
The Uses of LE 300
LE 300 is a potent and selective dopamine receptor antagonist.
What are the applications of Application
LE 300 is a potent and selective D1DR receptor antagonist
Definition
ChEBI: LSM-2007 is a member of indoles.
Biological Activity
Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .
Storage
Room temperature
Properties of LE 300
| Melting point: | >91°C (dec.) |
| storage temp. | Store at RT |
| solubility | DMSO: 26 mg/mL |
| form | solid |
| color | Off-White to Pale Beige |
| Stability: | Hygroscopic |
Safety information for LE 300
Computed Descriptors for LE 300
New Products
4-Iodo-3,5-dimethylbenzonitrile 2-fluoro-4-iodoaniline 2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 6,6'-methylenebis(9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one) 3-Bromo-2-fluorobenzoic acid Quinuclidine-4-carbonitrile N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (R)-1-Benzyl-3-pyrrolidinecarbonitrile Bupropian related compound F Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 1,4-bis(methylsulfonyl)butane 4-Cyano-N-Methacryloyl-3-Trifluoromethyl Aniline 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzeneRelated products of tetrahydrofuran
![2-phenyl-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol](https://img.chemicalbook.in/CAS/GIF/62717-42-4.gif)
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