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HomeProduct name listLAT-NET

LAT-NET

LAT-NET Structural

What is LAT-NET?

Description

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

The Uses of LAT-NET

13,14-Dihydro Bimatoprost can be used as reactant/reagent for preparation of nitrooxy prostamides for treatment of glaucoma. Analog or impurity of the drug Bimatoprost (B386800).

Definition

ChEBI: Latanoprost ethyl amide is a prostanoid.

Properties of LAT-NET

Boiling point: 640.9±55.0 °C(Predicted)
Density  1.095±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: 30 mg/ml; DMSO: 50 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 200 μg/ml
pka 14.84±0.70(Predicted)

Safety information for LAT-NET

Computed Descriptors for LAT-NET

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