L371,257
- CAS NO.：162042-44-6
- Empirical Formula: C28H33N3O6
- Molecular Weight: 507.58
- MDL number: MFCD00944944
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:57:00
What is L371,257?
The Uses of L371,257
L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.
What are the applications of Application
L-371,257 is a potent oxytocin receptor inhibitor
Biological Activity
Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.
Storage
Store at RT
Properties of L371,257
| Boiling point: | 728.9±60.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 10 mM in DMSO with gentle warming |
| form | Powder |
| pka | 0.73±0.20(Predicted) |
| color | White to off-white |
Safety information for L371,257
Computed Descriptors for L371,257
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 5-Bromo-2-Fluoropyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 4-Bromo-3-(ethoxymethyl)benzoic acid 2,4-Dichloro-5-methoxyaniline 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine N2-Isobutyryl-2'-O-methylguanosine 2-chloro-5-methylpyridin-4-amine 4-Bromobenzaldehyde 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amineRelated products of tetrahydrofuran
![4-[3-(Dimethylamino)propoxy]benzaldehyde](https://img.chemicalbook.in/CAS/GIF/26934-35-0.gif)
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