L-Prolinamide
- CAS NO.：7531-52-4
- Empirical Formula: C5H10N2O
- Molecular Weight: 114.15
- MDL number: MFCD00005253
- EINECS: 231-397-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-29 17:45:46
What is L-Prolinamide?
Chemical properties
Crystalline
Description
L-Prolinamide is a chemical compound that has been shown to inhibit the production of proinflammatory cytokines, making it a potential treatment for rheumatoid arthritis and other autoimmune diseases.
The Uses of L-Prolinamide
Proline based organocatalyst.
The Uses of L-Prolinamide
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. Also it is a efficient organocatalysts for aldol reactions on water.
The Uses of L-Prolinamide
L-Prolinamide is an important intermediate of synthetic polypeptide and chiral drug, also as the chiral ligand of asymmetry catalysis building-up reactions, is used for Robinson cyclization and Aldol reaction etc.
Definition
ChEBI: The carboxamide derivative of L-proline.
Preparation
Firstly, reacting L-proline as an initial raw material with triphosgene, diphosgene or phosgene in solvents of anhydrous tetrahydrofuran, 1,4-dioxane, dichlormethane, chloroform, acetonitrile and the like to synthesize L-proline carbamyl chloride of an intermediate state; secondly, further condensing in the presence of triethylamine to generate L-proline-N-carboxyl-anhydride; and finally, performing ammonolysis, and thus obtaining the L-prolinamide.
Properties of L-Prolinamide
| Melting point: | 95-97 °C (lit.) |
| Boiling point: | 213.66°C (rough estimate) |
| alpha | -106 º (c=2, EtOH) |
| Density | 1.1008 (rough estimate) |
| refractive index | 1.4720 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 16.21±0.20(Predicted) |
| form | Powder or Granules |
| color | White to straw |
| optical activity | [α]20/D 106°, c = 2 in ethanol |
| Water Solubility | Soluble in water and ethanol (50 mg/ml). |
| BRN | 80807 |
| CAS DataBase Reference | 7531-52-4(CAS DataBase Reference) |
Safety information for L-Prolinamide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for L-Prolinamide
| InChIKey | VLJNHYLEOZPXFW-BYPYZUCNSA-N |
L-Prolinamide manufacturer
JSK Chemicals
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