L 2-401

Synonym(s):4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione

CAS NO.：883050-24-6
Empirical Formula: C16H13FN2O2S
Molecular Weight: 316.35
MDL number: MFCD00113783
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is L 2-401?

Description

CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC₅₀ = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα₀, while blocking GTPase activity and Gα₀-dependent translocation of RGS4 to the membrane.

Properties of L 2-401

Density	1.398±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
form	powder
color	white to beige

Safety information for L 2-401

Computed Descriptors for L 2-401

New Products

Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 1-aminocyclobutanecarbonitrile hydrochloride AMINO-O-TOLYL-ACETIC ACID 1-Aminocyclobutanecarboxylic Acid Hydrochloride AMINO(2-BROMOPHENYL)ACETIC ACID 6-BROMOTETRAZOLO[1,5-A]PYRIDINE 3-Oxocyclobutanecarboxylic acid METHANE-D3-SULFONYL CHLORIDE N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D TERTIARY BUTANOL-D9 CHLOROFORM-D TOLUENE-D3 Methyl 6-(hydroxymethyl)nicotinate 4-Bromo-3-iodoaniline 2-(4-Bromophenyl)ethylamine 2,6-bis(bromomethyl)pyridine 5-Aminooxazole-4-carbonitrile 4-(piperazin-1-yl)benzene-1,2-diamine 1-(3-Chlorophenyl)piperazine hydrochloride