L 2-401

Synonym(s):4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione

CAS NO.：883050-24-6
Empirical Formula: C16H13FN2O2S
Molecular Weight: 316.35
MDL number: MFCD00113783
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 08:30:42

What is L 2-401?

Description

CCG-50014 is an inhibitor of regulator of G protein signaling 4 (RGS4) (IC₅₀ = 30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. RGS proteins bind to the Gα subunits of activated heterotrimeric G proteins and accelerate the rate of GTP hydrolysis, acting as GTPase-activating proteins. CCG-50014 irreversibly binds and destabilizes RGS4 with no effect on Gα₀, while blocking GTPase activity and Gα₀-dependent translocation of RGS4 to the membrane.

Properties of L 2-401

Density	1.398±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
form	powder
color	white to beige

Safety information for L 2-401

Computed Descriptors for L 2-401

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