KO-947
- CAS NO.：1695533-89-1
- Empirical Formula: C21H17N5O
- Molecular Weight: 355.39
- MDL number: MFCD31657422
- Update Date: 2026-06-03 11:24:09
What is KO-947?
Description
KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).
Properties of KO-947
| Boiling point: | 704.1±60.0 °C(Predicted) |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.32±0.20(Predicted) |
| color | White to off-white |
Safety information for KO-947
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for KO-947
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