KIN1408
Synonym(s):7-((4-(Difluoromethoxy)phenyl)(5-methoxybenzo[d]thiazol-2-ylamino)methyl)quinolin-8-ol;7-[[4-(Difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-8-quinolinol
- CAS NO.：1903800-11-2
- Empirical Formula: C25H19F2N3O3S
- Molecular Weight: 479.5
- Update Date: 2026-01-13 11:21:15
What is KIN1408?
Description
KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; ). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.
Properties of KIN1408
| Boiling point: | 675.6±65.0 °C(Predicted) |
| Density | 1.430±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM) |
| form | A solid |
| pka | 4.22±0.50(Predicted) |
| color | Light yellow to yellow |
Safety information for KIN1408
Computed Descriptors for KIN1408
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