KIN1408

Synonym(s):7-((4-(Difluoromethoxy)phenyl)(5-methoxybenzo[d]thiazol-2-ylamino)methyl)quinolin-8-ol;7-[[4-(Difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-8-quinolinol

CAS NO.：1903800-11-2
Empirical Formula: C25H19F2N3O3S
Molecular Weight: 479.5
Update Date: 2026-04-16 17:44:27

What is KIN1408?

Description

KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; ). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses.

Properties of KIN1408

Boiling point:	675.6±65.0 °C(Predicted)
Density	1.430±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM)
form	A solid
pka	4.22±0.50(Predicted)
color	Light yellow to yellow

Safety information for KIN1408

Computed Descriptors for KIN1408

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