Kif15-IN-1

CAS NO.：672926-32-8
Empirical Formula: C20H22N4O5S
Molecular Weight: 430.48
MDL number: MFCD28167755
Update Date: 2026-05-28 00:11:03

What is Kif15-IN-1?

Biological Activity

kif15-in-1, a potent kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].kif15,also known as kinesin-12 and hklp2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.kif15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with kif11 [3].

References

[1]. preparation of quinazolinediones as kif15 kinesin inhibitors for treating cellular proliferative disorders. pat. appl. publ. (2004), us 20040053948 a1 20040318.
[2]. buster d w, baird d h, yu w, et al. expression of the mitotic kinesin kif15 in postmitotic neurons: implications for neuronal migration and development[j]. journal of neurocytology, 2003, 32(1): 79-96.
[3]. vanneste d, takagi m, imamoto n, et al. the role of hklp2 in the stabilization and maintenance of spindle bipolarity[j]. current biology, 2009, 19(20): 1712-1717.

Properties of Kif15-IN-1

Density	1.361±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in DMSO; ≥19.2 mg/mL in EtOH
pka	7.73±0.50(Predicted)
form	Solid
color	White to off-white

Safety information for Kif15-IN-1

Computed Descriptors for Kif15-IN-1

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