ketomethylenebestatin
- CAS NO.：137028-97-8
- Empirical Formula: C17H25NO4
- Molecular Weight: 307.39
- Update Date: 2025-04-18 09:52:27
What is ketomethylenebestatin?
Description
Ketomethylenebestatin is a carba-analogue of the aminopeptidase (AP) inhibitor bestatin. This synthesis was carried out by a malonic ester alkylation with the suitably protected halomethyl ketone of (2S,3R)-AHPBA*), followed by a second alkylation with isobutyl bromide of the resulting 4-ketodiester, and subsequent decarboxylation and deprotection. Ketomethylenebestatin is 10 fold less effective as inhibitor of aminopeptidases than bestatin.
Properties of ketomethylenebestatin
| Boiling point: | 529.6±50.0 °C(Predicted) |
| Density | 1.158±0.06 g/cm3(Predicted) |
| pka | 4.51±0.23(Predicted) |
Safety information for ketomethylenebestatin
Computed Descriptors for ketomethylenebestatin
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