ketomethylenebestatin

CAS NO.：137028-97-8
Empirical Formula: C17H25NO4
Molecular Weight: 307.39
Update Date: 2025-04-18 09:52:27

What is ketomethylenebestatin?

Description

Ketomethylenebestatin is a carba-analogue of the aminopeptidase (AP) inhibitor bestatin. This synthesis was carried out by a malonic ester alkylation with the suitably protected halomethyl ketone of (2S,3R)-AHPBA*), followed by a second alkylation with isobutyl bromide of the resulting 4-ketodiester, and subsequent decarboxylation and deprotection. Ketomethylenebestatin is 10 fold less effective as inhibitor of aminopeptidases than bestatin.

Properties of ketomethylenebestatin

Boiling point:	529.6±50.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
pka	4.51±0.23(Predicted)

Safety information for ketomethylenebestatin

Computed Descriptors for ketomethylenebestatin

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