KDOAM-25

Synonym(s):2-[[[2-[2-(Dimethylamino)ethyl-Ethyl-Amino]-2-Oxidanylidene-Ethyl]amino]methyl]pyridine-4-Carboxamide;2-[[[2-[2-(dimethylamino)ethyl-ethylamino]-2-oxoethyl]amino]methyl]pyridine-4-carboxamide;GTPL8576;KDOAM-25;LQT

CAS NO.：2230731-99-2
Empirical Formula: C15H25N5O2
Molecular Weight: 307.39
MDL number: MFCD30146416
Update Date: 2026-01-05 11:31:08

What is KDOAM-25?

Biochem/physiol Actions

KDOAM25 is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. JARID1A and JARID1B are independently overexpressed in some cancers with JARID1B (KDM5B, PLU1) also identified as a potential oncogene, a repressor of tumour repressor genes. JARID1C (KDM5C) and JARID1D (KDM5D) are located on the X- and Y-chromosomes respectively. KDOAM25′s closest off-target is JMJD2C (selectivity >400 fold). It shows no activity on other tested 2-OG family members, including FIH, NO66, MINA53 and PHD2. KDOAM25 is active in cells.

Properties of KDOAM-25

Boiling point:	478.6±45.0 °C(Predicted)
Density	1.137±0.06 g/cm3(Predicted)
storage temp.	-20°C
pka	15.03±0.50(Predicted)

Safety information for KDOAM-25

Computed Descriptors for KDOAM-25

New Products

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