KDM2A/7A-IN-1

CAS NO.：2169272-46-0
Empirical Formula: C33H38N4O
Molecular Weight: 506.68
MDL number: MFCD32174259
Update Date: 2025-10-29 15:43:00

What is KDM2A/7A-IN-1?

Biological Activity

KDM2A/7A-IN-1 is a first-in-class, selective and cell-passing inhibitor of histone lysine demethylase KDM2A/7A with IC50 value of 0.16 μM for KDM2A It is 75 times more potent than other JmjC lysine demethylases, and has no effect on methyltransferases and histone acetyltransferases.

in vitro

KDM2A/7A-IN-1 ((S,S)-6) is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC ₅₀ of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive to methyl transferases, and histone acetyl transferases.
KDM2A/7A-IN-1 (0.4, 3.1, 6.2 μM) augments cellular H3K36me2 levels in HeLa cells ectopically expressing catalytically active KDM2A.

Properties of KDM2A/7A-IN-1

storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
color	Light yellow to yellow

Safety information for KDM2A/7A-IN-1

Computed Descriptors for KDM2A/7A-IN-1

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