K201 hemifumarate
Synonym(s):1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone;1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone hemifumarate;JTV-519;K201;K201 hemifumarate
- CAS NO.：145903-06-6
- Empirical Formula: C25H32N2O2S
- Molecular Weight: 424.6
- MDL number: MFCD23098915
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is K201 hemifumarate?
Biochem/physiol Actions
JTV-519 is a potent inhibitor or the ryanodine receptor 2 (RYR2) blocker. RYR2 is a cardiac calcium channel that regulates calcium levels in the sarcoplasmic reticulum. JTV-519 stabilizes RYR2 in the closed state.
Properties of K201 hemifumarate
| Boiling point: | 615.1±55.0 °C(Predicted) |
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 8.93±0.10(Predicted) |
| color | white to beige |
| BRN | 10598851 |
Safety information for K201 hemifumarate
| Signal word | Warning |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for K201 hemifumarate
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