JWH 210 N-(4-hydroxypentyl) metabolite

CAS NO.：1427521-37-6
Empirical Formula: C26H27NO2
Molecular Weight: 385.5
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:31

What is JWH 210 N-(4-hydroxypentyl) metabolite?

Description

JWH 210 is a potent cannabimimetic alkylindole that has been identified in extracts from herbal blends. Structurally and functionally similar alkylindoles are rapidly metabolized by the liver and secreted in the urine, with hydroxylation of the alkyl side chain occurring in the liver.^1,2,3 JWH 210 N-(4-hydroxypentyl) metabolite is an expected metabolite of JWH 210, detectable in the serum and urine. Its biological activities have yet to be determined.

The Uses of JWH 210 N-(4-hydroxypentyl) metabolite

JWH-210 4-Hydroxypentyl is a urinary metabolite of JWH-210 which is an analgesic chemical that acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors.

References

1. Teske, J., Weller, J.P., Fieguth, A., et al. Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometry J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(27),2659-2663(2010).
2. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
3. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).

Properties of JWH 210 N-(4-hydroxypentyl) metabolite

Boiling point:	601.3±45.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
solubility	DMF: 15 mg/ml; DMSO: 14 mg/ml; Ethanol: 15 mg/ml
form	A crystalline solid
pka	15.19±0.20(Predicted)

Safety information for JWH 210 N-(4-hydroxypentyl) metabolite

Computed Descriptors for JWH 210 N-(4-hydroxypentyl) metabolite

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