JWH 122 2-methylnaphthyl isomer

Description

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both central CB₁ (K_i = 0.69 nM) and peripheral CB₂ (K_i = 1.2 nM) receptors.^1,2 It has been detected in commercially-available herbal products.³ JWH 122 2-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

References

1. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor Bioorgan. Med. Chem. 11(4),539-549(2003).
2. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB₁ and CB₂ receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB₂ receptor agonists Bioorg. Med. Chem. 13(1),89-112(2005).
3. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3),109-115(2011).