JWG-071
Synonym(s):11-(sec-butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one;5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl-11-(1-methylpropyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
- CAS NO.：2250323-50-1
- Empirical Formula: C34H44N8O3
- Molecular Weight: 612.77
- Update Date: 2026-01-13 11:21:41
What is JWG-071?
Biological Activity
JWG-071 is the first reported ERK5 kinase-selective chemical probe which can increases ERK5 activity and BRD4 selectivity. It will be a much-needed chemical probe for deconvoluted ERK5 and BRD4 pharmacology.
in vitro
JWG-071 inhibits ERK5 and LRRK2 with IC 50 of 88 and 109 nM, respectively.
< /div>
Properties of JWG-071
| Boiling point: | 801.7±75.0 °C(Predicted) |
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 8.14±0.42(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for JWG-071
Computed Descriptors for JWG-071
New Products
Dexamethasone Sodium Phosphate p-Anisaldehyde m-Tolualdehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid Raloxifene EP Impurity D N-Nitroso Nortriptyline Nitroso Irbesartan 2-(p-Tolyl)acetaldehyde Sulfonic acid Impurity 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 5-Chloro-2-Methoxy-4-Picoline 2-Amino-6-nitrobenzoic Acid (6-Nitroanthranilic acid) Cis-3,5 Diacetoxy-1-cyclopentene 3-Bromo-2-Methoxy-4-Methylpyridine 2-Amino-5-Chloro-3-Nitro-6-picoline 3-Methoxy-5-methylpyrazin-2-amine Pentachlorobenzonitrile Budesonide Nicotinic acid RAPAMYCIN Alpha CyclodextrinYou may like
-
JWG-071 CAS 2250323-50-1View Details
2250323-50-1 -
12029-98-0 >98%View Details
12029-98-0 -
1177-87-3 Dexamethasone Acetate >98%View Details
1177-87-3 -
Hydrocortisone 50-23-7 >98%View Details
50-23-7 -
106-43-4 Parachlorotoluene >99%View Details
106-43-4 -
Pyrrolidin >98%View Details
123-75-1 -
cis-p-Menth-2,8-diene-1-ol 7212-40-0 >98%View Details
7212-40-0 -
Para Chloro toluene (PCT) 106-43-4 >99%View Details
106-43-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.