JWG-071
Synonym(s):11-(sec-butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one;5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl-11-(1-methylpropyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
- CAS NO.：2250323-50-1
- Empirical Formula: C34H44N8O3
- Molecular Weight: 612.77
- Update Date: 2026-01-13 11:21:41
What is JWG-071?
Biological Activity
JWG-071 is the first reported ERK5 kinase-selective chemical probe which can increases ERK5 activity and BRD4 selectivity. It will be a much-needed chemical probe for deconvoluted ERK5 and BRD4 pharmacology.
in vitro
JWG-071 inhibits ERK5 and LRRK2 with IC 50 of 88 and 109 nM, respectively.
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Properties of JWG-071
| Boiling point: | 801.7±75.0 °C(Predicted) |
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 8.14±0.42(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for JWG-071
Computed Descriptors for JWG-071
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