JW 618

CAS NO.：1416133-88-4
Empirical Formula: C17H14F6N2O2
Molecular Weight: 392.3
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 06:29:48

What is JW 618?

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JW 618 is an inhibitor of MAGL that displays IC₅₀ values of 123, 385, and 6.9 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.¹ JW 618 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC₅₀s all > 50 μM for mouse, rat, and human brain membranes).¹

References

1. Chang, J.W., Niphakis, M.J., Lum, K.M., et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chem. Biol. 19(5),579-588(2012).

Properties of JW 618

Boiling point:	380.0±42.0 °C(Predicted)
Density	1.349±0.06 g/cm3(Predicted)
solubility	DMF: 10 mg/ml; DMSO: 5 mg/ml; Ethanol: 16 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
pka	5.17±0.26(Predicted)

Safety information for JW 618

Computed Descriptors for JW 618

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