JT010

Synonym(s):2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide

CAS NO.：917562-33-5
Empirical Formula: C16H19ClN2O3S
Molecular Weight: 354.85
MDL number: MFCD08899142
Update Date: 2025-12-03 09:04:23

What is JT010?

Description

JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC₅₀ = 0.65 nM in a calcium influx assay). It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 μM.

The Uses of JT010

JT010 is a potent and selective TRPA1 channel activator (EC50 = 65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Biochem/physiol Actions

JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC50?= 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50?>1 μM).

Storage

Store at +4°C

Properties of JT010

Boiling point:	487.4±55.0 °C(Predicted)
Density	1.265±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder
pka	2.59±0.10(Predicted)
color	white to beige

Safety information for JT010

Computed Descriptors for JT010

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