JH-VIII-157-02
- CAS NO.：1639422-97-1
- Empirical Formula: C28H27N5O2
- Molecular Weight: 465.55
- MDL number: MFCD31657417
- Update Date: 2026-01-06 15:52:27
What is JH-VIII-157-02?
Biological Activity
JH-VIII-157-02, a structural analog of alectinib, is an ALK inhibitor with IC50 of 2 nM for echinoderms microtubule-associated protein-like 4 (EML4)-ALK G1202R.
in vivo
JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice.
Properties of JH-VIII-157-02
| Boiling point: | 751.9±60.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 25 mg/mL (53.70 mM) |
| pka | 13.70±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for JH-VIII-157-02
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for JH-VIII-157-02
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