JAK3 INHIBITOR VI

CAS NO.：856436-16-3
Empirical Formula: C18H13N3O.CH4O3S
Molecular Weight: 383.42
MDL number: MFCD09037543
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is JAK3 INHIBITOR VI?

What are the applications of Application

JAK3 Inhibitor VI is a cell permeable selective inhibitor of JAK3

General Description

A cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3) (IC₅₀ = 27 nM). Reported to bind to the enzyme active site and prevent IL-2-induced phosphorylation of JAK3 and STAT5. Also reported to inhibit IL-2-induced cell proliferation (IC₅₀ = 760 nM for murine CTLL cells and 250 nM for human T-cells). Shown to alleviate oxazolone-induced ear edema in mice with an efficacy comparable to Dexamethasone (Cat. No. 265005) and displays ~16-fold greater selectivity over JAK2.

Biochem/physiol Actions

Cell permeable: yes

Properties of JAK3 INHIBITOR VI

storage temp.	+2C to +8C
form	Yellow solid

Safety information for JAK3 INHIBITOR VI

Computed Descriptors for JAK3 INHIBITOR VI

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