J30-8

CAS NO.：2366255-71-0
Empirical Formula: C17H9ClFN3O2S
Molecular Weight: 373.79
MDL number: MFCD05026464
Update Date: 2026-01-13 11:24:15

What is J30-8?

Description

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases[1]. JNK3|40 nM (IC50)

References

[1]. Dou X, et al. Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases. J Med Chem. 2019 Jul 25;62(14):6645-6664.

Properties of J30-8

storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
color	Brown to red

Safety information for J30-8

Computed Descriptors for J30-8

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