ISOXANTHOHUMOL
Synonym(s):2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4,7-Dihydroxy-5-methoxy-8-prenylflavanone;Humulol;Isoxanthohumol;IXN
- CAS NO.：521-48-2
- Empirical Formula: C21H22O5
- Molecular Weight: 354.4
- MDL number: MFCD00238718
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:33
What is ISOXANTHOHUMOL?
Description
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.
The Uses of ISOXANTHOHUMOL
Isoxanthohumol is a prenylated flavone isolated from hop. A chromane-like cyclic prenylflavonoids for neurological disorder therapy. Isoxanthohumol is a prenylated flavonoid phytoestrogen which is an apoptosis inducer in mature adipocytes
What are the applications of Application
Isoxanthohumol is a prenylated flavonoid Phytoestrogen which is an apoptosis inducer in mature adipocytes
Definition
ChEBI: Isoxanthohumol is a member of flavanones.
Properties of ISOXANTHOHUMOL
| Melting point: | 183 - 187° |
| Boiling point: | 585.8±50.0 °C(Predicted) |
| Density | 1.245±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 7.90±0.40(Predicted) |
| color | Pale Yellow |
| BRN | 10199264 |
Safety information for ISOXANTHOHUMOL
Computed Descriptors for ISOXANTHOHUMOL
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