ISOTETRANDRINE

Description

A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]¹⁷_D + 146° or[α]²⁰_D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.

The Uses of ISOTETRANDRINE

Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

What are the applications of Application

Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2

References

Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
Synthesis:
Inubushi et ai., Tetrahedron Lett., 3399 (1968)