Isonanangenine B

CAS NO.：1623153-14-9
Empirical Formula: C21H32O6
Molecular Weight: 380.48
MDL number: MFCD33021275
Update Date: 2026-04-14 09:55:04

What is Isonanangenine B?

Biological Activity

Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus.1,2 It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 μM. Isonanagenine B (18.42 μM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

References

1.Lacey, H.J., Gilchrist, C.L.M., Crombie, A., et al.Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensisBeilstein J. Org. Chem.152631-2643(2019) 2.Felix, S., Sandjo, L.P., Opatz, T., et al.SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expressionBeilstein J. Org. Chem.92866-2876(2013)

Properties of Isonanangenine B

Boiling point:	541.9±50.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	-20°C
form	A solid
pka	11.46±0.70(Predicted)

Safety information for Isonanangenine B

Computed Descriptors for Isonanangenine B

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