ISOCORYDINE HYDROCHLORIDE

Synonym(s):11-Hydroxy-1,2,10-trimethoxyaporphine;Isocorydine hydrochloride;Luteanine

CAS NO.：475-67-2
Empirical Formula: C20H23NO4
Molecular Weight: 341.4
MDL number: MFCD00075905
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is ISOCORYDINE HYDROCHLORIDE?

Description

Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC₅₀ value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC₅₀ = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC₅₀s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.

The Uses of ISOCORYDINE HYDROCHLORIDE

Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.

The Uses of ISOCORYDINE HYDROCHLORIDE

sedative, cholinergic

The Uses of ISOCORYDINE HYDROCHLORIDE

Isocorydine is an alkaloid inhibitor of eukaryotic kinases.

Definition

ChEBI: Isocorydine is an aporphine alkaloid.

References

See Isocorydine

Properties of ISOCORYDINE HYDROCHLORIDE

Melting point:	216-220 °C(lit.)
Boiling point:	477.03°C (rough estimate)
alpha	D20 +195° (chloroform)
Density	1.2064 (rough estimate)
refractive index	1.5614 (estimate)
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Cryst.
pka	9.41±0.20(Predicted)